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ETF sheet · Issuer-declared data

L&G Pharma Breakthrough UCITS ETFIndex, costs, backtest, listings and taxation

ISIN: IE00BF0H7608Ticker: BIOTIssuer: LGIMClass: USD Acc.
Issuer-declared data
Declared index
Solactive Pharma Breakthrough Value Index Net TR USD
TER
0.49%
Transaction costs
0.13% (issuer estimate, from the KID)
Management
Passive (index-tracking) (from the KID)
Income policy
SFDR
Article 9 — declared sustainable investment objective what does it mean?
Sector (from holdings)
Health care98% of the declared portfolio (30 June 2026)
Fund assets
17.7 mln EUR
Domicile
Ireland
Inception date
23 January 2018
Data as declared by LGIM in the issuer’s official files and endpoints · collected on 2 September 2026 (monthly refresh). Facts only, no recommendation.
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Description

L&G Pharma Breakthrough UCITS ETF tracks the issuer-declared index: Solactive Pharma Breakthrough Value Index Net TR USD. The declared annual cost (TER) is 0.49%, plus 0.13% in transaction costs estimated by the issuer in the KID. Replication is full physical replication (the KID declares buying every index constituent); income is accumulated and reinvested in the fund. The fund has assets of about 18 million euro, was launched on 23 January 2018 and is domiciled in Ireland.

The fund’s objective — in the issuer’s words

The investment objective of the Fund is to provide exposure to bio-technology companies that are actively engaged in the research, development and/or manufacturing of orphan drugs. The Fund is passively managed and aims to track the performance of the Solactive Pharma Breakthrough Value Index Net Total Return (the “Index”), before the deduction of fees and expenses. The Index is designed to provide exposure to biotechnology companies worldwide that are actively engaged in the research, development and/or manufacturing of orphan drugs, in accordance with its methodology.

Keep reading the KID section ▾

The Fund seeks to achieve its investment objective by investing primarily in equity securities that, as far as possible and practicable, make up the Index in similar proportions to their weightings in the Index. Where it is not possible or practicable to invest directly in all of the constituents of the Index, the Fund may also invest in equity related securities and instruments that are not constituents of the Index but have similar risk and performance characteristics, and may use financial derivative instruments for efficient portfolio management or to assist in tracking the performance of the Index. The Fund has a sustainable investment objective as it invests in companies which (i) contribute to social objectives, (ii) do not significantly harm any environmental or social objectives, and (iii) follow good governance practices. Further information can be found in the Fund Supplement. This Share Class does not intend to pay dividends. Any income which may result from the Fund's investments will be re-invested into the Fund. Shares in this Share Class (the "Shares") are denominated in USD and can be bought and sold on stock exchanges by ordinary investors using an intermediary (e.g. a stockbroker). In normal circumstances, only Authorised Participants may buy and sell Shares directly with the Company. Authorised Participants may redeem their Shares on demand in accordance with the "Dealing Timetable" published on http://www.lgim.com.

The depositary of the Fund is the Bank of New York Mellon SA/NV, Dublin Branch. Further information about the Fund and the share class can be obtained from the Company's prospectus and the annual and semi-annual reports, which are available, in addition to the latest prices for the share class and details of any other share classes, free of charge at: www.lgim.com.

Intended Retail Investor:The Fund is designed for investors looking to grow their money in an investment which can form part of their existing savings portfolio. Although investors can take their money out at any time, the Fund may not be appropriate for those who plan to withdraw their money within five years. The Fund is not designed for investors who cannot afford more than a minimal loss of their investment.

From the KID’s “Objectives” section · 4 August 2026 · original document ↓
Text generated from the data the issuer declares in official product lists. No recommendation.

Quick reads

  • TER 0.49%: above the median of equity ETFs we track (0.22%).
  • Average tracking difference over the last 3 years: -0.44% p.a., against a declared TER of 0.49%.
Comparisons computed by Rebalix on the declared data in our census; they describe the past and are not indicative of future results.

Official documents

Key Information Document (KID)PDF in English, from the issuer’s site — always the latest filed versionProspectusPDF in English, from the issuer’s site — the fund’s full legal documentFactsheetPDF in Italian, from the issuer’s site — the fund’s monthly snapshot
The KID is the document the law requires you to read before investing: 3 pages covering risks, costs and scenarios. The link opens the issuer’s published PDF.

Fund performance

issuer-declared net asset value (NAV) · USD · from Jan 2018 to Sept 2026
Compare with another ETF
Only funds we hold a history for. Three at a time, at most.
Return
+55.8%
Annualised
+5.3%
Volatility (ann.)
18.6%
Max drawdown
-34.19%
-20%+1%+22%+44%+65%Jan 2018Mar 2020May 2022Jul 2024Sept 2026The break-even line: the value at the start of the period. Above it you are in gain, below in loss.break-even (0%)+56%Jan 2018Sept 2026
Note — currency risk: the fund is denominated (or hedged) in USD and the chart is in USD. For a euro investor, returns also depend on the EUR/USD exchange rate, up or down.
Tip: drag across the chart to zoom into a period.

Drawdown — distance from previous peak

This isn’t the return: it shows how far the fund is below its previous peak. 0% = you’re at the peak; below zero = how much you’re down and haven’t recovered yet.
0%-10%-20%-30%-40%-50%20182020202220242026−34.19% · 19 Apr 2024
Max drawdown
-34.19%
peak → trough
Trough
19 Apr 2024
from the 11 Feb 2021 peak
Recovery time
577 days
recovery only: trough to break-even · ≈ 1 year and 7 months
Underwater
1,740 days
decline + recovery: peak to break-even · ≈ 4 years and 9 months · → recovered on 17 Nov 2025

The five worst falls in the period

From the peak ofTroughDepthBack to break-evenDays underwater
11 Feb 202119 Apr 2024-34.19%17 Nov 20251,740
19 Feb 202023 Mar 2020-27.35%27 Apr 202068
28 Sept 201824 Dec 2018-22.51%21 Jan 2020480
26 Jan 201806 Apr 2018-11.32%17 Jul 2018172
07 Jul 202603 Aug 2026-10.43%19 Aug 202643

Calendar-year returns

2018
-7.9%
2019
12.7%
2020
27.1%
2021
-3.8%
2022
-7.3%
2023
-10.3%
2024
-4.8%
2025
36.8%
2026
13.5%

Month-by-month returns

JanFebMarAprMayJunJulAugSeptOctNovDecYear
20260.31.5-3.22.60.18.1-5.09.7-0.413.5
20254.35.3-3.60.50.5-0.85.96.46.05.14.4-1.736.8
2024-5.2-1.1-0.2-5.23.41.96.46.8-3.1-1.10.5-6.8-4.8
20234.0-4.9-2.93.5-3.8-3.13.3-2.4-6.1-7.26.53.7-10.3
2022-6.0-1.12.3-5.9-4.01.11.8-3.2-4.23.18.80.7-7.3
2021-0.2-3.0-2.51.70.24.8-3.13.9-3.50.7-4.11.7-3.8
20201.2-2.0-8.017.96.80.80.84.2-1.5-6.27.45.527.1
20197.75.0-1.5-5.5-5.37.6-3.0-2.5-5.38.810.9-2.712.7
2018-5.3-1.20.04.60.45.86.20.2-14.54.7-8.3-7.9
From month-end NAVs, over the fund’s full history, on the series shown in the chart (dividends reinvested where declared). Deeper colour = larger move.
Source: LGIM. Issuer-declared historical series; inflation: Eurostat and national statistical institutes, latest available July 2026 — for later days the index stays at the last published value (institutes publish with a few weeks’ lag). The «adjusted for inflation» view expresses value in today’s purchasing power for the selected country; volatility always stays nominal, as elsewhere on the site (deflating it would add artificial swings caused by the monthly cadence of the price index). Past performance is not indicative of future results: these are facts, not a recommendation.

Tracking difference — fund vs index

How much the fund returned above (+) or below (−) its index, year by year. It measures the actual deviation: the combined effect of costs (TER and transaction), securities-lending revenue and replication optimisations — which is why it can beat the TER. Tracking difference was positive in 0 of the last 7 calendar years: a past observation, not an indication of future outperformance.
Average TD (last 3 years)
-0.44% /anno
Declared TER
0.49%
YearFundIndexDifference
2025+36.81%+37.28%-0.47%
2024-4.81%-4.29%-0.52%
2023-10.26%-9.94%-0.33%
2022-7.26%-6.86%-0.41%
2021-3.85%-3.57%-0.28%
2020+27.09%+28.09%-1.00%
2019+12.67%+13.45%-0.78%
Total-return figures from issuer-declared series (primary source); complete calendar years. TD is not comparable across sites using different methodologies or index variants. Past performance is not indicative of future results. What is tracking difference? →

Risk indicators· EUR

Last yearLast 3 yearsLast 5 yearsFull history
Volatility (ann.)17.97%16.60%17.03%18.60%
Max drawdown-11.22%-19.96%-28.32%-28.90%
Sharpe1.190.460.130.31
Sortino1.760.650.180.44
Computed from the daily NAV series, always in nominal terms. Sharpe and Sortino use the ECB main refinancing rate averaged over the period (last year: 2.21%), weighted by days in force, as the risk-free rate. Same formulas as our public methodology: sample standard deviation annualised over 252 days; Sortino with downside deviation. Past performance is not indicative of future results. Figures in EUR — series converted day by day at ECB reference rates; the table follows the currency selected in the chart.

Portfolio holdings

Top-10 weight
35.9%

Top 10 holdings

Travere Therapeutics
5.20%
Xencor
4.50%
Ligand Pharmaceuticals
3.60%
Xeris Biopharma
3.50%
Jazz Pharmaceuticals
3.50%
Royalty Pharma
3.20%
Incyte Corporation
3.10%
Mirum Pharmaceuticals
3.10%
Bridgebio Pharma Inc
3.10%
Halozyme
3.10%

Sectors

Assistenza sanitaria
97.9%
Materiali di base
2.1%

Countries

AfghanistanAngolaAlbaniaUnited Arab EmiratesArgentinaArmeniaFrench Southern and Antarctic LandsAustraliaAustriaAzerbaijanBurundiBelgiumBeninBurkina FasoBangladeshBulgariaThe BahamasBosnia and HerzegovinaBelarusBelizeBoliviaBrazilBruneiBhutanBotswanaCentral African RepublicCanadaSwitzerlandChileChinaIvory CoastCameroonDemocratic Republic of the CongoRepublic of the CongoColombiaCosta RicaCubaCyprusCzech RepublicGermanyDjiboutiDenmark: 2.7%Dominican RepublicAlgeriaEcuadorEgyptEritreaSpain: 2.5%EstoniaEthiopiaFinlandFijiFalkland IslandsFrance: 2.6%GabonUnited Kingdom: 3.2%GeorgiaGhanaGuineaGambiaGuinea BissauEquatorial GuineaGreeceGreenlandGuatemalaFrench GuianaGuyanaHondurasCroatiaHaitiHungaryIndonesiaIndiaIreland: 3.5%IranIraqIcelandIsraelItalyJamaicaJordanJapan: 8.9%KazakhstanKenyaKyrgyzstanCambodiaSouth KoreaKosovoKuwaitLaosLebanonLiberiaLibyaSri LankaLesothoLithuaniaLuxembourgLatviaMoroccoMoldovaMadagascarMexicoMacedoniaMaliMyanmarMontenegroMongoliaMozambiqueMauritaniaMalawiMalaysiaNamibiaNew CaledoniaNigerNigeriaNicaraguaNetherlandsNorwayNepalNew ZealandOmanPakistanPanamaPeruPhilippinesPapua New GuineaPolandPuerto RicoNorth KoreaPortugalParaguayQatarRomaniaRussiaRwandaWestern SaharaSaudi ArabiaSudanSouth SudanSenegalSolomon IslandsSierra LeoneEl SalvadorSomaliaRepublic of SerbiaSurinameSlovakiaSloveniaSweden: 3%SwazilandSyriaChadTogoThailandTajikistanTurkmenistanEast TimorTrinidad and TobagoTunisiaTurkeyTaiwanUnited Republic of TanzaniaUgandaUkraineUruguayUnited States of America: 62.1%UzbekistanVenezuelaVietnamVanuatuWest BankYemenSouth AfricaZambiaZimbabwe
up to 1%1–5%5–15%15–30%over 30%
Hover a country for its percentage.
Top 7 countries
United States62.1%
Japan8.9%
Ireland3.5%
United Kingdom3.2%
Sweden3%
Cayman Islands2.9%
Denmark2.7%
Top 10 holdings and breakdowns as declared by LGIM in the fund factsheet, data as of 30 June 2026. Percentages may not sum to 100 due to cash, derivatives and rounding.
Fund historyFund-assets (AUM) chart year by year and monthly basket snapshots.Open the history →

Where it shows up commission-free in Italy

According to the official lists published by the brokers (downloaded and cross-checked by us), these share classes of the fund appear tradable with zero fees:

IE00BF0H7608
  • Directazero within the savings plan (buys)
  • Directazero on single buys from 2,000 €, agreement until 31 December 2026
  • Moneyfarmzero within the savings plan (buys), agreement until 29 June 2029
  • Moneyfarmzero on single buys from 1,000 €, agreement until 29 June 2029
Full terms, traps and method in the observatory: Free savings plans and zero-commission ETFs: the broker survey

Official lists verified on 3 September 2026. We record published terms — this is neither an invitation to open accounts nor a recommendation: lists change, the broker’s documents prevail. Trade Republic, Scalable Capital and Trading 212 publish no per-ISIN lists and don’t appear here.

Stock exchange listings

ExchangeTickerTrading since
Borsa Italiana (ETFplus)BIOT23 Feb 2018
Börse DüsseldorfETLI20 Apr 2020
Börse FrankfurtETLI20 Apr 2020
Börse HamburgETLI20 Apr 2020
Börse HannoverETLI9 Dec 2024
Börse München / gettexETLI12 Sept 2019
Börse StuttgartETLI20 Apr 2020
Euronext AmsterdamBIOT1 Feb 2018
Tradegate ExchangeETLI20 Apr 2020
Xetra (Deutsche Börse)ETLI20 Apr 2020
+ 13 more trading venues (MTFs and professional platforms).
Trading venues from the official ESMA register (FIRDS); per-exchange tickers from the issuer’s tax documents and official listings. A dash “—” = that venue does not publish the item (ticker, currency or start date) in the sources we read. The same fund may trade in different currencies depending on the exchange: check the trading currency with your broker. Non-EU listings (e.g. UK, Mexico) not included.

Frequently asked questions

Which index does L&G Pharma Breakthrough UCITS ETF track?
The issuer LGIM declares the benchmark: Solactive Pharma Breakthrough Value Index Net TR USD.
How much does BIOT cost?
The issuer-declared TER is 0.49% per year; the transaction costs estimated in the KID are 0.13%.
What is the fund size of BIOT?
The fund size declared by LGIM is about 18 million euro.
When was BIOT launched?
The fund was launched on 23 January 2018: it has 8 years of history.
How does BIOT replicate its index?
It is a passively managed ETF: it follows the declared index. Physical (full replication) (issuer wording: “Fisica - replica completa (dal KID)”).
Does BIOT pay dividends?
No: it is an accumulating share class — income stays in the fund and is reinvested automatically (issuer wording: “Accumulating”).
Where does BIOT trade?
Per the official ESMA register it trades on 10 main exchanges, including Borsa Italiana (ETFplus) (BIOT), Börse Düsseldorf (ETLI), Börse Frankfurt (ETLI), Börse Hamburg (ETLI), Börse Hannover (ETLI), Börse München / gettex (ETLI).
What was BIOT's worst fall?
Over the available history (since 2018), the maximum drawdown was -34.19%, reached in April 2024. Past performance is not indicative of future results.
What is BIOT's tracking difference?
Over the last 3 complete calendar years the fund returned on average -0.44% per year versus its index (from issuer-declared series).
Transparency note
The data in this sheet is declared by LGIM in the issuer’s official files and endpoints, collected by Rebalix with a monthly refresh; taxation derives from the issuer’s tax documents (Italian Law Decree 138/2011). This is factual information for informational purposes only: it is not financial or tax advice, nor an investment recommendation. Read the fund’s KID and prospectus before investing.